New Guiding Principles For Cancer Genomics: Understanding Chromosome Reshuffling, Looking To The Genome’s 3D Structure

A good illustration of some of the complexities of cancer genomics and how our understanding is improving. Although a bit technical, this is readable. Summary quote:

Our finding that broken chromosome segments are more likely to join with other segments within the same chromosome, rather than other, more physically distant segments from other chromosomes, likely has great relevance to cancer genomes,” Alt continued. “For example, cancer treatments that cause breaks may preferentially lead to intra-chromosomal rearrangements. It may also have relevance for ‘chromothripsis,’ a recently discovered phenomenon in many cancers in which the sequences of one chromosome become scrambled.” 

New Guiding Principles For Cancer Genomics: Understanding Chromosome Reshuffling, Looking To The Genome’s 3D Structure.

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