Stem Cell Transplants Come Back to Haunt

Not surprising, there is a longer-term cost to aggressive treatments like allogeneic stem cell transplants. But without them, we would be dead, so a reasonable trade-off. Quote:

Overall, the presence of hypertension, diabetes, and dyslipidemia was significantly higher among hematopoietic cell transplant HCT recipients compared with the general population, according to Saro H. Armenian, DO, MPH, of City of Hope in Duarte, Calif., and colleagues.

Importantly, those who received hematopoietic cells from a donor had a greater risk of developing these cardiovascular risk factors compared with autologous cells transplant recipients, researchers reported online in Blood: Journal of the American Society of Hematology.

The authors pointed to two factors that could increase the cardiovascular risk in these patients:

  • Pre-transplant chemotherapy and radiation
  • Treatment for the transplant complication of graft-versus-host disease GVHD

Stem Cell Transplants Come Back to Haunt.


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