While written in ‘medicalese’, some progress in earlier detection of mantle cell lymphoma, but still at the research stage. Given that many of us are diagnosed at stage III or IV, further progress in earlier detection would be progress. But a number of years away in terms of clinical impact. Quote:
In mantle cell lymphoma patients, however, immunohistochemically detectable infiltrates of mantle cell lymphoma cells antedating the lymphoma diagnosis were found in a significant proportion of cases (10/37=27%). These consisted either of early mantle cell lymphoma with mantle zone growth pattern, or small extranodal accumulations of cyclin D1+ cells, whereas typical mantle cell lymphoma ‘in situ’ was not detected.