Gatenby’s Gambit – Lower Chemo Doses | Exploreable

Some interesting research looking at alternative approaches to chemotherapy dosing, essentially seeing if lower doses can be as or more effective, with the benefit of fewer side effects. Quote:

They [Robert Gatenby’s group] found that adaptive chemotherapy (where chemotherapy is used in doses that does not eliminate all of the susceptible cancer cells, reducing toxicity in the process) in the presence of 2-deoxyglucose and verapamil could significantly delay time to disease progression (increasing tumour burden in the presence of the drug). The work provides an interesting perspective on how chemotherapy might best be used and challenges the assumption that maximal doses are optimal.

Gatenby’s Gambit. | Exploreable.


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