The Miracle Drug That Could Kill All Cancers

Another bit of research that sounds promising, although the article may hype it up a bit. Essentially, a variant of immunotherapy, blocking a ‘do not eat’ signal normally displayed on tumour cells, thus allowing the immune system to do its work. Has been applied to lymphomas and leukemias, so will need to add this to the list of questions for my team next time. Quote:

“What we’ve shown is that CD47 isn’t just important on leukemias and lymphomas. It’s on every single human primary tumor that we tested… We showed that even after the tumor has taken hold, the antibody can either cure the tumor or slow its growth and prevent metastasis.”

The Miracle Drug That Could Kill All Cancers.

And a more detailed article, with all the caveats, concluding:

Anti-CD47 antibodies are definitely a promising discovery and a treatment to watch. I hope the research pans out and we can add this to our available treatments for cancer. It is possible, even probable, that (if the treatment proves safe and effective) in the future we may test cancers for the presence of CD47, and then give the treatment only to those who express this protein – further individualizing cancer treatment. Human studies are likely to take 5-10 years, however, and that’s if everything goes well.

2 thoughts on “The Miracle Drug That Could Kill All Cancers

  1. Just a couple of problems I see, and which some articles on the web have already pointed out; one would be the microenvironment of tumours and the ease of delivery, secondly, they haven’t tested it in orthotopic models yet, from what I’ve read (where metastasis is a feature) or on xenografts derived from metastatic disease.

    It is quite promising, though, as is the potential use of autophagy (where you get cells to eat themselves, See http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933174/ for a paper documenting this).

What do you think?